2023

1. Hoffmann WG, Chen YQ, Schwartz CS, Barber JL, Dev PK, Reasons RJ, Miranda Maravi JS, Armstrong B, Gerszten RE, Silbernagel G, Konrad RJ, Bouchard C, Sarzynski MA. Effects of Exercise Training on ANGPTL3/8 and ANGPTL4/8 and their Associations with Cardiometabolic Traits. J Lipid Res. 2024; 65(2): 100495. PMID: 38160757. doi: 10.1016/j.jlr.2023.100495. 

2. Hota M, Barber JL, Ruiz-Ramie JJ, Schwartz CS, Lam DTUH, Rao P, Mi MY, Katz DH, Robbins JM, Clish CB, Gerszten RE, Sarzynski MA, Ghosh S, Bouchard C. Omics-driven investigation of the biology underlying intrinsic submaximal working capacity and its trainability. Physiol Genomics. 2023 Nov 1;55(11):517-543. PMID: 37661925. doi: 10.1152/physiolgenomics.00163.2022.

3. Benson MD, Eisman AS, [28 more  authors], TOPMed Consortium, Bouchard C, Sarzynski MA, Rich SS, Rotter JI, Wang TJ, Wilson JG, Clish CB, Sarkar IN, Natarjan P, Gerszten RE.  Protein-metabolite association studies identify novel proteomic determinants of metabolite levels in human plasma. Cell Metab. 2023 Sep 5;35(9):1646-1660.e3. PMID: 37582364. doi: 10.1016/j.cmet.2023.07.012.

4. Samani SL, Barlow SC, Freeburg LA, Jones TL, Poole M, Sarzynski MA, Zile MR, Shazly T, Spinale FG. Left Ventricle Function and Post-Transcriptional Events with Exercise Training in Pigs. Plos ONE (in press)

5. Mi M, Barber JL, Rao P, Farrell LA, Sarzynski MA, Bouchard C, Robbins JM, Gerszten RE. Plasma Proteomic Kinetics in Response to Acute Exercise. Molecular & Cellular Proteomics 2023; 22: 100601. DOI: 10.1016/j.mcpro.2023.100601

6. Silbernagel G, Chen YQ, Rief M, Kleber ME, Hoffman M, Stojakovic T, Sarzynski MA, Marz W, Qian Y, Schanagl H, Konrad RJ. Apolipoprotein C-II Is Associated with Cardiovascular Mortality in a Manner Consistent with its Modulation of Lipoprotein Lipase Activity. European Heart Journal 2023; 00: 1-11. PMID: 37155355 DOI: 10.1093/eurheartj/ehad261

7. Robbins JM, Rao P, Deng S, Keyes MJ, Tahir UA, Katz DH, Beltran PMJ, Marchildon F, Barber JL, Peterson B, Gao Y, Correa A, Wilson JG, Smith JG, Cohen P, Ross R, Bouchard C, Sarzynski MA, Gerszten RE. Plasma proteomic changes in response to exercise training are associated with cardiorespiratory fitness adaptations. JCI Insight. 2023 Apr 10;8(7):e165867. doi: 10.1172/jci.insight.165867. PMID: 37036009; PMCID: PMC10132160 https://doi.org/10.1172/jci.insight.165867

8.  Cronje HT, Mi MY, Austin TR, Biggs ML, Siscovick D, Lemaitre R, Psaty BM, Tracy R, Djousee L, Kizer J, Ix JH, Sotoodehnia N, Rao P, Robbins JM, Barber JL, Sarzynski MA, Clish C, Bouchard C, Mukamak KJ, Gerszten RE, Jensen MK. Plasma proteomic determinants of glucose-insulin homeostasis and incident type 2 diabetes: Insights from the Cardiovascular Health Study and HERITAGE Family Study. Diabetes 2023; Feb 7;db220628. PMID: 36749929 doi: 10.2337/db22-0628

9. Turner-McGrievy GM, Wilson MJ, Carswell J, Okpara N, Aydin H, Bailey S, Davey M, Hutto B, Wilcox S, Friedman DB, Sarzynski MA, Liese AD. A 12-week randomized pilot intervention comparing the Healthy US, Mediterranean, and Vegetarian dietary patterns of the US Dietary Guidelines for changes in body weight, hemoglobin A1c, blood pressure, and dietary quality among African American adults. Journal of Nutrition 2023; 53(2):579-587. PMID: 36894249 doi: 10.1016/j.tjnut.2022.11.020.

10. Marini CF, Sisti D, Leon AS, Skinner JS, Sarzynski MA, Bouchard C, Rocchi MB, Piccoli G, Stocchi V, Federici A, Lucertini F. Accounting for individual characteristics makes the %HRR-%V̇O₂R relationship neither 1:1 nor more accurate. European J Sports Sci 2023; 8: 1600-1611. PMID: 35960537 DOI: 10.1080/17461391.2022.2113441

2022​

1. Barber JL, Ruiz-Ramie JJ, Robbins JM, Gerszten RE, Leon AS, Rao DC, Skinner JS, Bouchard C, Sarzynski MA. Regular exercise and patterns of response across multiple cardiometabolic traits: The HERITAGE Family Study. Br J Sports Med 2022; 56: 95-100. PMID: 33619128. DOI: 10.1136/bjsports-2020-103323

2. Sarzynski MA, Rice T, Perusse L, Tremblay A, Stanforth PR, Tchernof A, Barber JL, Robbins JM, Ghosh S, Gerszten RE, Leon AS, Skinner JS, Rao DC, Bouchard C. The HERITAGE Family Study: A Review of the Effects of Exercise on Cardiometabolic Health. Med Sci Sports Exerc 2022; 54(5S):S1-S43. PMID: 35611651, PMCID: PMC9012529 doi: 10.1249/MSS.0000000000002859

3. Wang Z et al. Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention. Nature Genetics 2022; 54: 1332-1344. PMID: 36071172. PMCID: PMC9470530 DOI: 10.1038/s41588-022-01165-1

4. Katz DH et al. Whole Genome Sequence Analysis of the Plasma Proteome in Black Adults. Circulation 2022; 145: 357-370. PMID: 34814699. DOI: 10.1161/CIRCULATIONAHA.121.055117

5. Katz DH, Robbins JM, Deng S, Tahir UA, Bick AG, Pampana A, Yu Z, Ngo D, Benson MD, Chen ZZ, Cruz DE, Gao Y, Bouchard C, Sarzynski MA, Correa A, Natarajan P, Wilson JG, Gerszten RE. Proteomic Profiling Platforms Head-to-Head: Leveraging Genetics and Clinical Traits in Human Populations to Compare Aptamer- and Antibody-based Methods. Science Advances 2022; 8: eabm5164. PMID: 35984888 PMCID: PMC9390994 DOI: 10.1126/sciadv.abm5164

6. Tahir UA, Katz DH, Avila-Pachecho J, Bick AG, Pampana A, Robbins JM, Yu ZY, Chen ZZ, Benson MD, Cruz DE, Ngo D, Deng S, Shi X, Zheng S, Eisman AS, Farrell L, Hall ME, Correa A, Tracy RP, Durda P, Taylor KD, Liu Y, Johnson WC, Guo X, Yao J, Chen YI, Manichaiku AWl, Ruberg FL, Blaner WS, Jain D, NHLBI Trans-Omics for Precision Medicine 1 Consortium, Bouchard C, Sarzynski MA, Rich SS, Rotter JI, Wang TJ, Wilson JG, Clish CB, Natarajan P, Gerszten RE. Whole Genome Association Study of the Plasma Metabolome Identifies Novel Metabolites Linked to Cardiometabolic Disease in Black Individuals. Nature Communications 2022; 14: 4923. PMID: 35995766 PMCID: PMC9395431 DOI: 10.1038/s41467-022-32275-3

7. Sparks JR, Sarzynski MA, Davis JM, Grandjean PW, Wang X. Cross-Sectional and Individual Relationships between Physical Activity and Glycemic Variability. Translational Journal of the American College of Sports Medicine 2022; 7: 1-12. PMID: 36091485 doi: 10.1249/tjx.0000000000000207

8. Smith AB, Gay JL, Emerson DM, Sarzynski MA, Arent SM, Torres-McGehee TM. Examination of the Prevalence of Female Athlete Triad Components among Competitive Cheerleaders. IJERPH 2022; 19(3): 1375. PMID: 35162393

9. Smith AB, Gay JL, Monsma E, Arent SM, Sarzynski MA, Emerson DM, Torres-McGehee TM.  Investigation of Eating Disorder Risk and Body Image Dissatisfaction among Female Competitive Cheerleaders. IJERPH 2022; 19(4): 2196. PMID: 35206381

10. Marini CF, Sisti D, Leon AS, Skinner JS, Sarzynski MA, Bouchard C, Rocchi MB, Piccoli G, Stocchi V, Federici A, Lucertini F. Accounting for individual characteristics makes the %HRR-%V̇O₂R relationship neither 1:1 nor more accurate. European J Sports Sci 2022. PMID: 35960537 DOI: 10.1080/17461391.2022.2113441

11. Sui X, Sarzynski MA, Gribben N, Zhang J, Lavie CJ. Cardiorespiratory Fitness and the Risk of All-cause, Cardio-vascular and Cancer Mortality in Men with Hypercholesterolemia. J of Clinical Medicine 2022; 11: 5211.      PMID: 36079141 PMCID: PMC9457072 DOI: 10.3390/jcm11175211

12. Dai J, Boghossian NS, Sarzynski MA, Luo F, Sun X, Li J, Fiehn O, Liu J, Chei L. Metabolome-Wide Associations of Gestational Weight Gain in Pregnant Women with Overweight and Obesity. Metabolites 2022; 12: 960. doi.org/10.3390/metabo12100960

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2021​

1. Robbins JM, Peterson B, Schranner D, Tahir U, Rienmuller T, Keyes M, Katz D, Baumgartner C, Jean Beltran PM, Carr SA, Ghosh S, , Sarzynski MA, Bouchard C, Gerszten RE. Plasma proteomic profiles of cardiorespiratory fitness. Nature Metabolism 2021; 3(6): 786-797.. PMID: 34045743. doi: 10.1038/s42255-021-00400-z

2. Fix DK, Counts BR, Smuder AJ, Sarzynski MA, Koh H, Carson JA. Wheel Running Improves Fasting-induced AMPK Signaling in Skeletal Muscle from Tumor Bearing Mice. Physiological Reports. 2021; 9:e14924. https://doi.org/10.14814/phy2.14924

3. Ruiz-Ramie JJ, Barber JL, Lloyd-Jones DM, Gross MD, Rana JS, Sidney S, Jacobrs DR, Lane-Cordova AD, Sarzynski MA. Cardiovascular Health Trajectories and Elevated C-Reactive Protein: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. Journal of American Heart Association 2021; 10: e019725. DOI: https://doi.org/10.1161/jaha.120.019725

4. Takeshita L, Davidsen PL, Herbert JM, Antczak P, Hesselink MKC, Schrauwen P, Rice TK, Weisnagel SJ, Bergman RN, Rao DC, Robbins JM, Gerszten RE, Ghosh S, Sarzynski MA, Bouchard C, Falciani F. Genomics and transcriptomics landscapes associated to changes in insulin sensitivity in response to endurance exercise. Scientific Reports. 2021; 11: 23314. PMID: 34857871. DOI: 10.1038/s41598-021-98792-1

5. Marini CF, Sisti D, Leon AS, Skinner JS, Sarzynski MA, Bouchard C, Rocchi MB, Piccoli G, Stocchi V, Federici A, Lucertini F. HRR & VO₂R fractions are not equivalent: Is it time to rethink aerobic exercise prescription methods? Medicine & Science in Sports & Exercise 2021; 53: 174-182. PMID: 32694364. DOI: 10.1249/MSS.0000000000002434

6. Sparks JR, Kishman EE, Sarzynski MA, Davis JM, Grandjean PW, Durstine JL, Wang X. Glycemic Variability: Importance, Relationship with Physical Activity, and the Influence of Exercise-A Brief Review. Sports Medicine & Health Science 2021; 3: 183-189. PMID: 35783368 PMCID: PMC9219280. DOI: https://doi.org/10.1016/j.smhs.2021.09.004

7. Sparks JR, Sarzynski MA, Davis JM, Grandjean PW, Wang X. Alterations in Glycemic Variability, Vascular Health, and Oxidative Stress following a 12-Week Aerobic Exercise Intervention-A Pilot Study. Int J Exerc Sci 2021; 14: 1334-1353. PMID: 35096240 PMCID: PMC8758171

 

2020​

1. Sarzynski MA and Bouchard C. World-class athletic performance and genetic endowment. Nature Metabolism 2020; 2: 796-798. PMID: 32943784. DOI: 10.1038/s42255-020-0233-6

2. Vellers, HL, Verhein KC, Burkholder AB, Lee J, Kim Y, Lightfoot JT, Shi M, Weinberg C, Rakinen T, Sarzynski MA, Bouchard, C. Association between Mitochondrial DNA Sequence and Heteroplasmy with maximal Oxygen Uptake Trainability. Medicine & Science in Sports & Exercise 2020; 52: 2303-2309. DOI: 10.1249/MSS.0000000000002390

3. Murthy VL, Baldridge AS, Carnethon MR, Sidney S, Bouchard C, Sarzynski MA, Lima JAC, Lewis GD, Shah SJ, Shah RV. Polygenetic risk, fitness and obesity: the Coronary Artery Risk Development in Youth (CARDIA) Study. JAMA Cardiology 2020; 5(3): 40-48. PMID: 31913407. DOI: 10.1001/jamacardio.2019.5220

 

2019

1. Williams SA, Kivimaki M, Langenberg C, Hingorani AD, Casas JP, Bouchard C, Jonasson C, Sarzynski MA, Shipley MJ, Alexander L, Ash J, Bauer T, Chadwick J, Datta G, DeLisle RK, Hagar Y, Hinterberg M, Ostroff R, Weiss S, Ganz P, Wareham N. Plasma protein patterns as comprehensive indicators of health. Nature Medicine 2019; 25: 1851-1857. PMID: 31792462 DOI: 10.1038/s41591-019-0665-2

2. Ross LM*, Barber JL*, McLain AC, Weaver RG, Sui X, Blair SN, Sarzynski MA. The Association of Cardiorespiratory Fitness and Ideal Cardiovascular Health in the Aerobics Center Longitudinal Study. *equal authorship. Journal of Physical Activity & Health 2019; 16(11): 968-975. PMID: 31553947 DOI: 10.1123/jpah.2018-0220

3. Ross R, Goodpaster BH, Koch LG, Sarzynski MA, Kohrt WM, Johannsen NM, Skinner JS, Castro A, Irving BA, Noland RC, Sparks LM, Spielmann G, Day AG, Pitsch W, Hopkins WG, Bouchard C. Precision Exercise Medicine: Understanding How Exercise Response Varies. British Journal of Sports Medicine 2019; 53(18): 1141-1153. PMID: 30862704 DOI: 10.1136/bjsports-2018-100328

4. Robbins JM, Herzig M, Morningstar JE, Wilson J, Sarzynski MA, Bouchard C, Rankinen T, Gerszten RE. Dimethlyguanidino valeric acid predicts partial resistance to the metabolic health benefits of regular exercise. JAMA Cardiology 2019; 4(7): 636-643. PMID: 31166569 DOI: 10.1001/jamacardio.2019.1573

5. Weaver RG, Brazendale K, Hunt E, Sarzynski MA, Beets MW, White K. Disparities in Childhood Overweight and Obesity by Income: An epidemiological examination using three nationally representative datasets. International Journal of Obesity 2019; 43(6): 1210-1222. PMID: 30718822 DOI: 10.1038/s41366-019-0331-2

6. Barber JL, Zellers KN, Barringhaus KG, Bouchard C, Spinale FG, Sarzynski MA. The Effects of Exercise Training on Circulating Cardiovascular-related MicroRNAs. Scientific Reports 2019; 9:7527. PMID: 31101833 DOI: 10.1038/s41598-019-43978-x

7. Ghosh S, Hota M, Chai X, Kiranya J, Ghosh P, He Z, Ruiz-Ramie JJ, Sarzynski MA, Bouchard C. Exploring the underlying biology of intrinsic cardiorespiratory fitness through integrative analysis of genomic variants and muscle gene expression profiling. Journal of Applied Physiology (in press). PMID: 30605401 DOI: 10.1152/japplphysiol.00035.2018

8. Ruiz-Ramie JJ, Barber JL, Sarzynski MA. Effects of exercise on HDL functionality. Current Opinion in Lipidology 2019; 30: 16-23 PMID: 30480581 DOI: 10.1097/MOL.0000000000000568

9. Bornstein DB, Grieve GL, Clennin M, McLain AC, Whitsel LP, Hauret KG, Jones BH, Sarzynski MA. Which US States Pose the Greatest Threats to Military Readiness and Public Health? Public health policy and national security implications for a cross-sectional investigation of cardiorespiratory fitness and injuries among U.S. Army Recruits from 2010- 2013. Journal of Public Health Management and Practice 2019; 25: 36-44. PMID: 29319585 DOI: 10.1097/PHH.0000000000000778

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2018

1. Baird JF, Gaughan ME, Saffer HM, Sarzynski MA, Herter TM, Fritz SL, Den Ouden DB, Stewart JC. The effect of energy-matched exercise intensity on brain-derived neurotrophic factor and motor learning. Neurobiology of Learning and Memory 2018; 156: 33-44. PMID: 30359727 DOI: 10.1016/j.nlm.2018.10.008

2. Barber JL, Kraus WE, Church TS, Hagberg JM, Thompson PD, Bartlett DB, Beets MW, Blair SN, Earnest CP, Huffman KM, Landers-Ramos R, Leon AS, Rao DC, Seip RL, Skinner JS, Slentz CA, Wilund KR, Bouchard C, Sarzynski MA. Effects of Regular Endurance Exercise on GlycA: Combined Analysis of 14 Exercise Interventions. Atherosclerosis 2018; 277: 1-6. PMID: 30170218 DOI: 10.1016/j.atherosclerosis.2018.07.029

3. Sarzynski MA, Ruiz-Ramie JJ, Barber JL, Slentz CA, Apolzan JW, McGarrah RW, Harris MN, Church TS, Borja MS, He Y, Oda MN, Martin CK, Kraus WK, Rohatgi A. The effects of increasing exercise intensity and dose on multiple measures of high-density lipoprotein function. Arteriosclerosis Thrombosis and Vascular Biology 2018; 38: 943-952. PMID: 29437573 DOI: 10.1161/ATVBAHA.117.310307

4. Rao P, Merath K, Drigalenko E, Jadhav AYL, Komorowski RA, Goldblat MI, Rohatgi A, Sarzynski MA, Gawrieh S, Olivier M. Proteomic characterization of high-density lipoprotein particles in patients with non-alcoholic fatty liver disease. Clinical Proteomics 2018; 15:10. PMID: 29527140 DOI: 10.1186/s12014-018-9186-0

5. Miller KE, Martz DC, Stoner C, Jowers A, Taheri ML, Sarzynski MA, Wilkinson LW, Plaisance EP. Efficacy of an individualized telephone-based medical nutrition program on blood lipid and lipoprotein metabolism: results from Our Healthy Heart. Nutrition & Dietetics 2018; 75(1): 73-78. PMID: 29411495 DOI: 10.1111/1747-0080.12366

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2017

1. Clarke K, Ricciardi S, Pearson T, Bharudin I, Davidson PK, Bonomo M, Brina D, Scagliola A, Simpson DM, Beynon RJ, Khanim F, Ankers J, Sarzynski MA, Ghosh S, Pisconti A, Rozman J, Hrabe de Angelis M, Bunce C, Stewart C, Egginton S, Caddick M, Jackson M, Bouchard C, Biffo S, Falciani F. The Role of eIF6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-Expression Networks. Cell Reports 2017; 21(6): 1507-1520​ DOI: 10.1016/j.celrep.2017.10.040

2. Sui X, Sarzynski MA, Lee DC, Kokkinos P. Impact of changes in cardiorespiratory fitness on hypertension, dyslipidemia and survival: an overview of the epidemiological evidence. Progress in Cardiovascular Diseases 2017; 60(1): 56-66. PMID: 28274819 DOI: 10.1016/j.pcad.2017.02.006

3. Sui X, Sarzynski MA, Lee DC, Zhang J, Kokkinos P, Payne J, Blair SN. Longitudinal patterns of cardiorespiratory fitness can predict the development of hypertension among men and women. American Journal of Medicine 2017; 130(4): 469-476. PMID: 27986522 DOI: 10.1016/j.amjmed.2016.11.017

4. Sarzynski MA, Ghosh S, Bouchard C. Genomic and transcriptomic predictors of response levels to endurance exercise training. J Physiology 2017; 595 (9): 2931-2939. PMID: 27234805 PMCID: PMC5407970 DOI: 10.1113/JP272559

5. Graff et al. Genome-wide physical activity interactions in obesity ‒ a meta-analysis of 200,452 adults. PLoS Genetics 2017; 13 (4): e1006528. PMID: 28448500 DOI: 10.1371/journal.pgen.1006972 DOI: 10.1371/journal.pgen.1006528

6. Justice AE et al. Genome-Wide Meta-Analysis Accounting for Smoking Behavior Identifies Novel Loci for Obesity Traits. Nature Communications 2017; 8: 14977. PMID: 28443625 DOI: 10.1038/ncomms14977

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2016

1. Breneman C, Polinksi K, Sarzynski MA, Lavie CJ, Kokkinos PF, Ahmed A, Sui X.The impact of cardiorespiratory fitness levels on the risk of developing atherogenic dyslipidemia. American Journal of Medicine 2016; 129 (10): 1060-1066. PMID: 27288861 DOI: 10.1016/j.amjmed.2016.05.017

2. Sung YJ, Perusse L, Sarzynski MA, Fornage M, Sidney S, Sternfeld B, Rice TK, Terry G, Jacobs DR Jr, Katzmarzyk P, Carr JJ, Ghosh S, Rankinen T, Rao DC, Bouchard C. Genome-wide association of abdominal and visceral fat with replication of prior findings. International Journal of Obesity 2016; 40(4): 662-74. PMID: 26480920 PMCID: PMC4821694 DOI: 10.1038/ijo.2015.217

3. Ried et al. A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape in >170,000 individuals of the GIANT consortium. Nature Communications2016; 7: 13357. PMID: 27876822 DOI: 10.1038/ncomms13357

4. Sarzynski MA, Loos RJF, Lucia A, Perusse L, Roth SM, Wolfarth B, Rankinen T, Bouchard C. Advances in Exercise, Fitness, and Performance Genomics in 2015. Medicine & Science in Sports & Exercise 2016; 48(10): 1906-1916. PMID: 27183119 DOI: 10.1249/MSS.0000000000000982

5. Lu et al. New loci for body fat percentage reveal link between adiposity andcardiometabolic disease risk. Nature Communications 2016; 7: 10495. PMID: 26833246 DOI: 10.1038/ncomms10495

6. Kilpelainen et al. Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels Nature Communications 2016; 7: 10494. PMID: 2683309 DOI: 10.1038/ncomms10494

7. Rankinen T, Fuku N, Wolfarth B , Sarzynski MA, Alexeev DG, Ahmetov II, Boulay MR, Cieszczyk P , Eynon N, Garton F, Generozov EV, Govorun VM, Houweling PJ, Kawahara T, Kostryukova ES, Kulemin NA, Larin AK, Maciejewska-Karłowska A, Miyachi M, MuniesaCA, Murakami H , Naumov VA, Ospanova EA, Padmanabhan S, Pavlenko AV, Santiago C , Sawczuk M, Scott RA, Wang G , Yvert T, Perusse L , Rauramaa R, North K, Lucia A , PitsiladisY, Bouchard C. No Evidence of a Common DNA Variant Profile Specific to World Class Endurance Athletes. Plos ONE 2016; 11(1): e0147330 DOI: 10.1371/journal.pone.0147330

8. Shah RV, Murthy VL, Colangelo LA, Reis J, Venkatesh BA, Sharma R, Abbasi SA, Goff DC Jr, Carr JJ, Rana JS, Terry J, Bouchard C, Sarzynski MA, Eisman A, Neilan T, Das S, Jerosch-Herold M, Lewis CE, Carnethon M, Lewis GD, Lima JAC. Fitness in Young Adulthood is Associated with Improved Survival and Cardiovascular Risk: the Coronary Artery Risk Development in Young Adults study. JAMA Internal Medicine 2016; 176(1): 87-95. PMID: 26618471 DOI: 10.1001/jamainternmed.2015.6309